NIH ME/CFS Collaborative Research Center 2023-2028 (U54AI178855)

Participant Interactions
Opportunities to volunteer for studies.
Muscle Tissue
Sections of muscle from ME/CFS and control subjects.
Immune Cell Dysfunction
Classical monocyte and platelet function.
Cell-free RNA
Plasma RNA content before and after exercise.
Extracellular Vesicle Cargo
Protein and RNA cargo of vesicles from different tissues.
Multiomics
Comparison of multiple types of data.
Research Core
Skilled analysts will support projects with bioinformatics, data management and data integration.

NIH ME/CFS Collaborative Research Center 2017-2023 (U54NS105541)

Single Cell Transcriptomics
Sequencing of mRNA and microRNA from peripheral blood to identify specific dysregulated leukocytes.
Two-Day Cardiopulmonary Exercise Testing
Volunteers participated in exercise testing and sample collection at three locations.
Vesicles and Signaling
Examining the effect of exercise on extracellular vesicle cargo, inflammatory proteins, and metabolism.
MRI brain imaging displayed on a computer screen
Oxidative Stress and Neuroinflammation

Using MRI and PET imaging to measure levels of energy-related and inflammatory molecules in the central nervous system.

Other ENID Center Projects

Genomics
Examining the expression of genes in mitochondrial genomes.
Metabolism
Probing the utilization of mitochondrial oxidative phosphorylation vs. glycolysis in immune cells and accumulation of metabolites in plasma.
Microbiome
Comparing gut microbiota, including bacteria, eukaryotes, and viruses in ME/CFS patients and controls.
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